Diabetes insipidus sodium urine,


diabetes insipidus sodium urine

Acta Medica Margit-László, F. Each experiment lasted 5 hours. The value of creatinine, excreted during 5 hours, was given in mg per g body weight. We determined also the ratio Na:K.

diabetes insipidus sodium urine

The results diabetes insipidus sodium urine the animals with their infundibulum damaged are shown in Table I. In the animals with infundibular lesion, the concentration and excreted amount of the exam­ined ions rose the increase in the excretion of potassium was insignificant diabetes insipidus sodium urine, while — in contrast to intact animals — urinary volume and creatinine excre­tion became considerably less.

Table II shows the results for the hypophysectomized rats and rats which received a subcutaneous injection of 5 mg of cortisone Adreson, Organon, Oss 12 hours prior to the water load.

diabetes insipidus sodium urine

These were identical with those described in earlier communications [5, 6, 15]. The diuretic and saluretic actions of chloro­thiazide became less pronounced in rats with reduced creatinine excretion that had been hypophysectomized several weeks earlier.

diabetes insipidus sodium urine

When, on the other hand, hypophysectomized animals were given cortisone, the diuretic­­saluretic effect of chlorothiazide was intensified and the excretion of creatinine more pronounced. Discussion The administration of chlorothiazide elicited different reactions in pa­tients suffering from diabetes insipidus and those suffering from psychogenic polydipsia.

diabetes insipidus sodium urine

The discrepancy might seem surprising, a lack of ADH being re­sponsible for both conditions. Yet, while the production of ADH is inhibited by a disorder of the hypothalamo-neurohypophyseal system in diabetes insi­pidus, the brain centres are unimpaired in psychogenic polydipsia and it is the hypo-osmosis which prevents the mobilization of the hormone.

diabetes insipidus sodium urine

Even the symptoms are practically the same in both syndromes and the.